Discovery of potent and effective inhibitors containing sulfoxide structures targeting EML4-ALK rearrangement and EGFR mutant non-small cell lung cancer.

An, Baijiao; Fan, Yangyang; Li, Wei; Nie, Wenyan; Nie, Haoran; Wang, Mengxuan; Feng, Jie; Yao, Han; Zhang, Yin; Li, Xingshu; Tian, Geng

An, Baijiao; Fan, Yangyang; Li, Wei; Nie, Wenyan; Nie, Haoran; Wang, Mengxuan; Feng, Jie; Yao, Han; Zhang, Yin; Li, Xingshu; Tian, Geng.

Afiliação

An B; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Yantai, Shandong 264003, PR China.
Fan Y; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China.
Li W; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
Nie W; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China.
Nie H; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China.
Wang M; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China.
Feng J; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China.
Yao H; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
Zhang Y; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Yantai, Shandong 264003, PR China.
Li X; School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, PR China.
Tian G; School of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Yantai, Shandong 264003, PR China.

Bioorg Chem ; 138: 106653, 2023 09.

Article em En | MEDLINE | ID: mdl-37302317

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Ligantes; Receptores ErbB; Fosforilação; Mutação; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/química; Linhagem Celular Tumoral; Proteínas de Fusão Oncogênica/genética; Proteínas de Fusão Oncogênica/metabolismo

Palavras-chave

ALK; Apoptosis; Dual kinase inhibitor; EGFR; Non-small cell lung cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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