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Preclinical risk assessment strategy to mitigate the T-cell dependent immunogenicity of protein biotherapeutics: State of the art, challenges and future perspectives.
Di Ianni, Andrea; Barbero, Luca; Fraone, Tiziana; Cowan, Kyra; Sirtori, Federico Riccardi.
Afiliação
  • Di Ianni A; University of Turin, Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (T
  • Barbero L; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.
  • Fraone T; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy.
  • Cowan K; New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck KGaA, Frankfurterstrasse 250, 64293 Darmstadt, Germany.
  • Sirtori FR; NBE-DMPK Innovative BioAnalytics, Merck Serono RBM S.p.A., an affiliate of Merck KGaA, Darmstadt, Germany, Via Ribes 1, 10010 Colleretto Giacosa (TO), Italy. Electronic address: federico.riccardi-sirtori@merckgroup.com.
J Pharm Biomed Anal ; 234: 115500, 2023 Sep 20.
Article em En | MEDLINE | ID: mdl-37311374
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Anticorpos Monoclonais Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Anticorpos Monoclonais Idioma: En Ano de publicação: 2023 Tipo de documento: Article