A nanobody-based complement inhibitor targeting complement component 2 reduces hemolysis in a complement humanized mouse model of autoimmune hemolytic anemia.

Chen, Jin Y; Zhang, Lingjun; Luo, Liping; Yang, Maojing; Chen, Yinghua; Lin, Feng

Chen, Jin Y; Zhang, Lingjun; Luo, Liping; Yang, Maojing; Chen, Yinghua; Lin, Feng.

Afiliação

Chen JY; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
Zhang L; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
Luo L; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
Yang M; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America.
Chen Y; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, United States of America.
Lin F; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States of America. Electronic address: linf2@ccf.org.

Clin Immunol ; 253: 109678, 2023 08.

Article em En | MEDLINE | ID: mdl-37315680

Assuntos

Anemia Hemolítica Autoimune; Complemento C2; Camundongos; Animais; Complemento C2/metabolismo; Hemólise; Ativação do Complemento; Inativadores do Complemento

Palavras-chave

AIHA; C2; Classical pathway; Complement; Lectin pathway; Nanobody

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C2 / Anemia Hemolítica Autoimune Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complemento C2 / Anemia Hemolítica Autoimune Idioma: En Ano de publicação: 2023 Tipo de documento: Article