CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/ß-catenin signaling pathway.

Han, Haijun; Xu, Mengxiang; Wang, Ju; Li, Ming D; Yang, Zhongli

Han, Haijun; Xu, Mengxiang; Wang, Ju; Li, Ming D; Yang, Zhongli.

Afiliação

Han H; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi
Xu M; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi
Wang J; VIT University, Chennai, India.
Li MD; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi
Yang Z; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Chi

J Adv Res ; 58: 129-138, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37321345

Assuntos

Via de Sinalização Wnt; beta Catenina; Humanos; Camundongos; Animais; beta Catenina/genética; beta Catenina/metabolismo; Depressão/metabolismo; Edição de Genes; Sistemas CRISPR-Cas; Glicogênio Sintase Quinase 3 beta/genética; Glicogênio Sintase Quinase 3 beta/metabolismo; Sacarose; Receptores Frizzled/genética; Receptores Frizzled/metabolismo

Palavras-chave

CRISPR/Cas9; Cell proliferation; Depression; FZD6; Wnt/ß-catenin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta Catenina / Via de Sinalização Wnt Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta Catenina / Via de Sinalização Wnt Idioma: En Ano de publicação: 2024 Tipo de documento: Article