Preclinical evaluation of the CDK4/6 inhibitor palbociclib in combination with a PI3K or MEK inhibitor in colorectal cancer.

Lee, Cha Len; Cremona, Mattia; Farrelly, Angela; Workman, Julie A; Kennedy, Sean; Aslam, Razia; Carr, Aoife; Madden, Stephen; O'Neill, Brian; Hennessy, Bryan T; Toomey, Sinead

Lee, Cha Len; Cremona, Mattia; Farrelly, Angela; Workman, Julie A; Kennedy, Sean; Aslam, Razia; Carr, Aoife; Madden, Stephen; O'Neill, Brian; Hennessy, Bryan T; Toomey, Sinead.

Afiliação

Lee CL; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Cremona M; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Farrelly A; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Workman JA; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Kennedy S; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Aslam R; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Carr A; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Madden S; Data Science Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
O'Neill B; Department of Radiation Oncology, St. Luke's Radiation Oncology Centre, Beaumont Hospital, Dublin 9, Ireland.
Hennessy BT; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
Toomey S; Medical Oncology Group, Department of Molecular Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.

Cancer Biol Ther ; 24(1): 2223388, 2023 12 31.

Article em En | MEDLINE | ID: mdl-37326340

Assuntos

Neoplasias Colorretais; Fosfatidilinositol 3-Quinases; Humanos; Fosfatidilinositol 3-Quinases/metabolismo; Linhagem Celular Tumoral; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Inibidores de Fosfoinositídeo-3 Quinase/farmacologia; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Quinases de Proteína Quinase Ativadas por Mitógeno; Proliferação de Células; Quinase 4 Dependente de Ciclina

Palavras-chave

Colorectal cancer; Gedatolisib; S6rp (S240/244); drug combinations; palbociclib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Fosfatidilinositol 3-Quinases Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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