Growth hormone replacement in adults with cured acromegaly: Efficacy and safety.
Best Pract Res Clin Endocrinol Metab
; 37(6): 101790, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37328323
ABSTRACT
Between 2% and 60% of patients with cured acromegaly may eventually develop growth hormone deficiency. In adults, growth hormone deficiency is associated with abnormal body composition, decreased exercise capacity and quality of life, dyslipidemia, insulin resistance and increased cardiovascular risk. Similar to patients with other sellar lesions, the diagnosis of growth hormone deficiency in adults with cured acromegaly generally requires stimulation testing, with the exception of patients with very low serum insulin-like growth factor I levels and multiple additional pituitary hormone deficiencies. In adults with cured acromegaly, growth hormone replacement may have beneficial effects on body adiposity, muscle endurance, serum lipids and quality of life. Growth hormone replacement is generally well-tolerated. Arthralgias, edema, carpal tunnel syndrome and hyperglycemia may occur in patients with cured acromegaly, as is true of patients with growth hormone deficiency of other etiologies. However, there is evidence of increased cardiovascular risk in some studies of growth hormone replacement in adults with cured acromegaly. More studies are needed to fully establish the beneficial effects and elucidate the risks of growth hormone replacement in adults with cured acromegaly. Until then, growth hormone replacement can be considered in these patients on a case-by-case basis.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Acromegalia
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Hormônio do Crescimento Humano
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Nanismo Hipofisário
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Hipopituitarismo
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article