Design, synthesis and evaluation of new pyrimidine derivatives as EGFR<sup>C797S</sup> tyrosine kinase inhibitors.

Mao, Yu-Ze; Xi, Xiao-Xiao; Zhao, Hong-Yi; Zhang, Yin-Liang; Zhang, San-Qi

Design, synthesis and evaluation of new pyrimidine derivatives as EGFR^C797S tyrosine kinase inhibitors.

Mao, Yu-Ze; Xi, Xiao-Xiao; Zhao, Hong-Yi; Zhang, Yin-Liang; Zhang, San-Qi.

Afiliação

Mao YZ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, PR China.
Xi XX; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, PR China.
Zhao HY; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, PR China.
Zhang YL; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, PR China.
Zhang SQ; Department of Medicinal Chemistry, School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, Shaanxi, PR China. Electronic address: sqzhang@xjtu.edu.cn.

Bioorg Med Chem Lett ; 91: 129381, 2023 07 15.

Article em En | MEDLINE | ID: mdl-37336419

Assuntos

Antineoplásicos; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Receptores ErbB; Neoplasias Pulmonares/tratamento farmacológico; Antineoplásicos/química; Simulação de Acoplamento Molecular; Mutação; Inibidores de Proteínas Quinases/química; Pirimidinas/química; Resistencia a Medicamentos Antineoplásicos

Palavras-chave

C797S mutation; Fourth-generation EGFR tyrosine kinase inhibitors; Non-small cell lung cancer; Pyrimidine derivatives; Synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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