Gradients of neurotransmitter receptor expression in the macaque cortex.
Nat Neurosci
; 26(7): 1281-1294, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37336976
ABSTRACT
Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1A receptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1A expression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mapeamento Encefálico
/
Córtex Cerebral
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Receptores de Neurotransmissores
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article