The secret life of chromatin tethers.
FEBS Lett
; 597(22): 2782-2790, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37339933
ABSTRACT
The nuclear envelope plays an essential role in organizing the genome inside of the nucleus. The inner nuclear membrane is coated with a meshwork of filamentous lamin proteins that provide a surface to organize a variety of cellular processes. A subset of nuclear lamina- and membrane-associated proteins functions as anchors to hold transcriptionally silent heterochromatin at the nuclear periphery. While most chromatin tethers are integral membrane proteins, a limited number are lamina-bound. One example is the mammalian proline-rich 14 (PRR14) protein. PRR14 is a recently characterized protein with unique function that is different from other known chromatin tethers. Here, we review our current understanding of PRR14 structure and function in organizing heterochromatin at the nuclear periphery.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Cromatina
/
Heterocromatina
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article