miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the NFAT2 to reduce F2RL2 expression.
Regen Med
; 18(7): 543-559, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37340944
ABSTRACT
Aim:
To explore the effect of miR-125b-5p/nuclear factor of activated T cells 1 (NFAT2)/F2RL2 on myocardial infarction (MI).Method:
After establishment of MI mouse model and oxygen glucose deprivation (OGD)-induced cell model, the effects of NFAT2 on the process of MI were observed, the effects of miR-125b-5p/NFAT2/F2RL2 on the cell viability, apoptosis, and inflammatory factors levels were determined.Result:
NFAT2 silencing relieved MI and inhibited the inflammation in MI model mice. In OGD-induced human coronary artery endothelial cells and human cardiac microvascular endothelial cells, miR-125b-5p enhanced cell viability, yet repressed cell apoptosis and inflammatory factors and NFAT2 levels. NFAT2 overexpression reversed the effects of miR-125b-5p, while F2RL2 silencing offset the effects of NFAT2 overexpression.Conclusion:
MiR-125b-5p alleviates MI injury by inhibiting NFAT2 level to reduce F2RL2 expression.
This research proves that miR-125b-5p reduces the level of F2RL2 by preventing the activation of NFAT2 pathway, thereby reducing cardiogenic vascular endothelial cell damage and inflammation (heat, swelling and redness). This may provide a new treatment for heart attacks.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article