Relaxed targeting rules help PIWI proteins silence transposons.

Gainetdinov, Ildar; Vega-Badillo, Joel; Cecchini, Katharine; Bagci, Ayca; Colpan, Cansu; De, Dipayan; Bailey, Shannon; Arif, Amena; Wu, Pei-Hsuan; MacRae, Ian J; Zamore, Phillip D

Gainetdinov, Ildar; Vega-Badillo, Joel; Cecchini, Katharine; Bagci, Ayca; Colpan, Cansu; De, Dipayan; Bailey, Shannon; Arif, Amena; Wu, Pei-Hsuan; MacRae, Ian J; Zamore, Phillip D.

Afiliação

Gainetdinov I; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. ildar.gainetdinov@umassmed.edu.
Vega-Badillo J; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Cecchini K; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Bagci A; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Colpan C; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
De D; Voyager Therapeutics, Cambridge, MA, USA.
Bailey S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Arif A; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Wu PH; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
MacRae IJ; Beam Therapeutics, Cambridge, MA, USA.
Zamore PD; RNA Therapeutics Institute and Howard Hughes Medical Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Nature ; 619(7969): 394-402, 2023 Jul.

Article em En | MEDLINE | ID: mdl-37344600

Assuntos

Proteínas Argonautas; Elementos de DNA Transponíveis; Inativação Gênica; RNA de Interação com Piwi; Animais; Camundongos; Proteínas Argonautas/classificação; Proteínas Argonautas/genética; Proteínas Argonautas/metabolismo; Elementos de DNA Transponíveis/genética; RNA de Interação com Piwi/genética; RNA de Interação com Piwi/metabolismo; Evolução Molecular; Fosfatos/metabolismo; Especificidade por Substrato

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Elementos de DNA Transponíveis / Inativação Gênica / Proteínas Argonautas / RNA de Interação com Piwi Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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