Novel spiroindoline quinazolinedione derivatives as anticancer agents and potential FLT3 kinase inhibitors.

Divar, Masoumeh; Edraki, Najmeh; Damghani, Tahereh; Moosavi, Fatemeh; Mohabbati, Maryam; Alipour, Alireza; Pirhadi, Somayeh; Saso, Luciano; Khabnadideh, Soghra; Firuzi, Omidreza

Divar, Masoumeh; Edraki, Najmeh; Damghani, Tahereh; Moosavi, Fatemeh; Mohabbati, Maryam; Alipour, Alireza; Pirhadi, Somayeh; Saso, Luciano; Khabnadideh, Soghra; Firuzi, Omidreza.

Afiliação

Divar M; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Edraki N; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Damghani T; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Moosavi F; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohabbati M; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Alipour A; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Pirhadi S; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Saso L; Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, P. le Aldo Moro 5, Rome, Italy.
Khabnadideh S; Pharmaceutical Sciences Research center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: khabns@sums.ac.ir.
Firuzi O; Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: firuzio@sums.ac.ir.

Bioorg Med Chem ; 90: 117367, 2023 07 15.

Article em En | MEDLINE | ID: mdl-37348260

Assuntos

Antineoplásicos; Leucemia; Humanos; Linhagem Celular Tumoral; Quinazolinonas/farmacologia; Antineoplásicos/farmacologia; Antineoplásicos/metabolismo; Ciclo Celular; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/metabolismo; Proliferação de Células; Apoptose; Ensaios de Seleção de Medicamentos Antitumorais; Relação Estrutura-Atividade; Simulação de Acoplamento Molecular; Tirosina Quinase 3 Semelhante a fms/metabolismo

Palavras-chave

Anticancer drug; Drug design; FLT3; Kinase inhibitor; Receptor tyrosine kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article