Sesquiterpenes from Streptomyces qinglanensis and Their Cytotoxic Activity.
Mar Drugs
; 21(6)2023 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-37367686
ABSTRACT
Nine sesquiterpenes, including eight pentalenenes (1-8) and one bolinane derivative (9), were isolated from the culture broth of a marine-derived actinobacterium Streptomyces qinglanensis 213DD-006. Among them, 1, 4, 7, and 9 were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds 4-6 and 8 showed a moderate activity against all of the tested solid cell lines, with GI50 values ranging from 1.97 to 3.46 µM.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
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Streptomyces
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Antineoplásicos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article