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Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.
Salah, Mohamed; Tahoun, Mariam; Rudzitis-Auth, Jeannette; Stotz, Lisa; van Koppen, Chris J; Laschke, Matthias W; Abdelsamie, Ahmed S; Frotscher, Martin.
Afiliação
  • Salah M; Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, 66123 Saarbrücken, Germany.
  • Tahoun M; Department of Pharmaceutical Chemistry, School of Pharmacy, Newgiza University (NGU), Newgiza, km 22 Cairo-Alexandria Desert Road, 12577 Cairo, Egypt.
  • Rudzitis-Auth J; Department of Pharmacy, Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C23, 66123 Saarbrücken, Germany.
  • Stotz L; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.
  • van Koppen CJ; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany.
  • Laschke MW; Department of Obstetrics & Gynecology, Saarland University Hospital, 66421 Homburg, Germany.
  • Abdelsamie AS; ElexoPharm GmbH, Campus A12, 66123 Saarbrücken, Germany.
  • Frotscher M; Institute for Clinical and Experimental Surgery, Saarland University, 66421 Homburg, Germany.
J Med Chem ; 66(13): 8975-8992, 2023 07 13.
Article em En | MEDLINE | ID: mdl-37369108
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esteril-Sulfatase / Endometriose Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esteril-Sulfatase / Endometriose Idioma: En Ano de publicação: 2023 Tipo de documento: Article