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Comprehensive Study of Anti-UVC Activity and Cytotoxicity of Hot-water Soluble Herb Extracts.
Izawa, Maki; Otaka, Yusei; Sakagami, Hiroshi; Tanuma, Sei-Ichi; Amano, Shigeru; Uota, Shin; Inomata, Megumi; Kato, Yuka; Kadokura, Hiroshi; Yokose, Satoshi; Sunaga, Katsuyoshi; Koga-Ogawa, Yukari; Nakaya, Giichirou; Kito, Shinji.
Afiliação
  • Izawa M; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan; izawa@dent.meikai.ac.jp sakagami@dent.meikai.ac.jp.
  • Otaka Y; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
  • Sakagami H; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
  • Tanuma SI; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
  • Amano S; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
  • Uota S; Meikai University Research Institute of Odontology (M-RIO), Saitama, Japan.
  • Inomata M; Division of Microbiology and Immunology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Saitama, Japan.
  • Kato Y; Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
  • Kadokura H; Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
  • Yokose S; Division of Endodontics and Operative Dentistry, Department of Restorative and Biomaterials Sciences, Meikai University School of Dentistry, Saitama, Japan.
  • Sunaga K; Laboratory of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan.
  • Koga-Ogawa Y; Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
  • Nakaya G; Faculty of Health Sciences, Nihon Institute of Medical Science, Saitama, Japan.
  • Kito S; Division of Dental Radiology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Saitama, Japan.
In Vivo ; 37(4): 1540-1551, 2023.
Article em En | MEDLINE | ID: mdl-37369486
BACKGROUND/AIM: COVID-19 pandemic caused the rapid dissemination of ultraviolet C (UVC) sterilization apparatuses. Prolonged exposure to UVC, however, may exert harmful effects on the human body. The aim of the present study was to comprehensively investigate the anti-UVC activity of a total of 108 hot-water soluble herb extracts, using human dermal fibroblast and melanoma cell lines, for the future development of skin care products. MATERIALS AND METHODS: Exposure time to UVC was set to 3 min, and cell viability was determined using the MTT assay. Anti-UVC activity was determined using the selective index (SI), a ratio of 50% cytotoxic concentration for unirradiated cells to 50% effective concentration that restored half of the UVC-induced decrease of viability. RESULTS: Dermal fibroblasts at any population doubling level were more resistant to UVC irradiation than melanoma cells. Both 49 herb extracts recommended by Japan Medical Herb Association (JAMHA) and 59 additional herb extracts showed comparable anti-UVC activity. SI values of selected herbs (Butterbur, Cloves, Curry Tree, Evening Primrose, Rooibos, Stevia, Willow) were several-fold lower than those of vitamin C and vanillin. Their potent anti-UVC activity was maintained for at least 6 h post irradiation, but declined thereafter to the basal level, possibly due to cytotoxic ingredients. CONCLUSION: UVC sensitivity may be related to the growth potential of target cells. Removal of cytotoxic ingredients of herb extracts may further potentiate and prolong their anti-UVC activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Melanoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 / Melanoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article