The Interplay between Dysregulated Metabolism and Epigenetics in Cancer.
Biomolecules
; 13(6)2023 06 05.
Article
em En
| MEDLINE
| ID: mdl-37371524
ABSTRACT
Cellular metabolism (or energetics) and epigenetics are tightly coupled cellular processes. It is arguable that of all the described cancer hallmarks, dysregulated cellular energetics and epigenetics are the most tightly coregulated. Cellular metabolic states regulate and drive epigenetic changes while also being capable of influencing, if not driving, epigenetic reprogramming. Conversely, epigenetic changes can drive altered and compensatory metabolic states. Cancer cells meticulously modify and control each of these two linked cellular processes in order to maintain their tumorigenic potential and capacity. This review aims to explore the interplay between these two processes and discuss how each affects the other, driving and enhancing tumorigenic states in certain contexts.
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MEDLINE
Assunto principal:
Neoplasias
Idioma:
En
Ano de publicação:
2023
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Article