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Scale-free correlations and potential criticality in weakly ordered populations of brain cancer cells.
Wood, Kevin B; Comba, Andrea; Motsch, Sebastien; Grigera, Tomás S; Lowenstein, Pedro R.
Afiliação
  • Wood KB; Department of Biophysics, University of Michigan, Ann Arbor, MI, USA.
  • Comba A; Department of Physics, University of Michigan, Ann Arbor, MI, USA.
  • Motsch S; Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
  • Grigera TS; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Lowenstein PR; School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA.
Sci Adv ; 9(26): eadf7170, 2023 06 28.
Article em En | MEDLINE | ID: mdl-37379380
ABSTRACT
Collective behavior spans several orders of magnitude of biological organization, from cell colonies to flocks of birds. We used time-resolved tracking of individual glioblastoma cells to investigate collective motion in an ex vivo model of glioblastoma. At the population level, glioblastoma cells display weakly polarized motion in the (directional) velocities of single cells. Unexpectedly, fluctuations in velocities are correlated over distances many times the size of a cell. Correlation lengths scale linearly with the maximum end-to-end length of the population, indicating that they are scale-free and lack a characteristic decay scale other than the size of the system. Last, a data-driven maximum entropy model captures statistical features of the experimental data with only two free parameters the effective length scale (nc) and strength (J) of local pairwise interactions between tumor cells. These results show that glioblastoma assemblies exhibit scale-free correlations in the absence of polarization, suggesting that they may be poised near a critical point.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article