γδ-T cell with high toxic potential was associated with recurrent miscarriage.
Am J Reprod Immunol
; 90(1): e13717, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37382173
ABSTRACT
PROBLEM:
RM is a common clinical disease in reproduction, affecting approximately 1%-3% of women worldwide. Previous studies have shown the role of peripheral blood γδ-T cells during physiological pregnancy. However, the relationship between the immune status of peripheral blood γδ-T cells and RM is still not well defined. METHOD OF STUDY In this study, mid-luteal peripheral blood from 51 RM patients and 40 healthy women was collected to determine the immune status of γδ-T cells. The percentage of peripheral blood γδ-T cells, and the molecules mediating their toxic potential, including cytotoxic granules (perforin, granzyme B, and granulysin) and receptors (NKG2D, CD158a, and CD158b), were detected by flow cytometry.RESULTS:
Compared to healthy control, an increase in the proportion of total CD3+ T cells in lymphocytes and a decrease in the ratio of γδ-T cells to CD3+ T cells were observed in patients with RM. The percentages of granzyme B+ γδ-T cells and CD158a+ γδ-T cells in total γδ-T cells or lymphocytes were significantly increased in patients with RM, compared with healthy control. Conversely, CD158b+ γδ-T cells in total γδ-T cells or lymphocytes were significantly decreased in the RM group.CONCLUSION:
Increased peripheral blood γδ-T cell with high toxic potential was associated with RM.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Aborto Habitual
/
Linfócitos Intraepiteliais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article