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Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer.
Han, Xin; Zhao, Lijie; Xiang, Weiguo; Miao, Bukeyan; Qin, Chong; Wang, Mi; Xu, Tianfeng; McEachern, Donna; Lu, Jianfeng; Wang, Yu; Metwally, Hoda; Yang, Chao-Yie; Kirchhoff, Paul D; Wang, Lu; Matvekas, Aleksas; Takyi-Williams, John; Wen, Bo; Sun, Duxin; Ator, Mark; Mckean, Robert; Wang, Shaomeng.
Afiliação
  • Han X; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Zhao L; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Xiang W; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Miao B; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Qin C; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang M; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Xu T; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • McEachern D; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Lu J; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang Y; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Metwally H; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Yang CY; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Kirchhoff PD; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang L; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Matvekas A; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Takyi-Williams J; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wen B; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Sun D; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Ator M; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Mckean R; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
  • Wang S; The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States.
J Med Chem ; 66(13): 8822-8843, 2023 07 13.
Article em En | MEDLINE | ID: mdl-37382562
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Receptores Androgênicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Receptores Androgênicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article