A selective autophagy receptor VISP1 induces symptom recovery by targeting viral silencing suppressors.
Nat Commun
; 14(1): 3852, 2023 06 29.
Article
em En
| MEDLINE
| ID: mdl-37385991
ABSTRACT
Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor. We previously identified a virus-induced small peptide called VISP1 as a selective autophagy receptor that facilitates virus infections by targeting components of antiviral RNA silencing. However, we show here that VISP1 can also inhibit virus infections by mediating autophagic degradation of viral suppressors of RNA silencing (VSRs). VISP1 targets the cucumber mosaic virus (CMV) 2b protein for degradation and attenuates its suppression activity on RNA silencing. Knockout and overexpression of VISP1 exhibit compromised and enhanced resistance against late infection of CMV, respectively. Consequently, VISP1 induces symptom recovery from CMV infection by triggering 2b turnover. VISP1 also targets the C2/AC2 VSRs of two geminiviruses and enhances antiviral immunity. Together, VISP1 induces symptom recovery from severe infections of plant viruses through controlling VSR accumulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cucumovirus
/
Infecções por Citomegalovirus
/
Traumatismos Craniocerebrais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article