The Interactions between Maternal Iron Supplementation and Iron Metabolism-Related Genetic Polymorphisms on Birth Outcomes: A Prospective Study in Chinese.
J Nutr
; 153(8): 2442-2452, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-37390907
ABSTRACT
BACKGROUND:
The effect of iron supplementation during pregnancy on birth outcomes may vary with maternal genetic background and needs more investigation.OBJECTIVES:
This prospective study aimed to evaluate the interactions between maternal iron supplementation and iron metabolism-related genetic polymorphisms on birth outcomes.METHODS:
This was a substudy from a community-based randomized control trial conducted in Northwest China, which included 860 women from the 2 micronutrient supplementation groups (folic acid [FA] and FA + iron group). Maternal peripheral blood, sociodemographic and health-related information, and neonatal birth outcomes were collected. Six single nucleotide polymorphisms in iron metabolism-related genes were genotyped. The alleles associated with decreased iron/hemoglobin status were used as the effect alleles. The genetic risk score (GRS) that reflected the genetic risk of low iron/hemoglobin status was estimated using the unweighted and weighted methods. Generalized estimating equations with small-sample corrections were applied to evaluate the interactions between iron supplementation and SNPs/GRS on birth outcomes.RESULTS:
There were significant interactions between maternal iron supplementation and rs7385804 (P = 0.009), rs149411 (P = 0.035), rs4820268 (P = 0.031), the unweighted GRS (P = 0.018), and the weighted GRS (P = 0.009) on birth weight. Compared with FA supplementation only, FA + iron supplementation significantly increased birth weight among women with more effect alleles in rs7385804 (ß 88.8 g, 95% CI 9.2, 168.3) and the GRSs (the highest unweighted GRS, ß 135.5 g, 95% CI 7.7, 263.4; the highest weighted GRS, ß 145.9 g, 95% CI 43.4, 248.5); it had a trend of decreasing birth weight and increasing low birth weight risk among women with fewer effect alleles.CONCLUSIONS:
In our population, maternal genetic background related to iron metabolism plays a significant role in determining the efficacy of iron supplementation. Routine iron supplementation could be more beneficial to fetal weight growth among mothers with higher genetic risk for low iron/hemoglobin status.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
/
Ferro
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article