Lymphocyte-to-white blood cell ratio is associated with outcome in patients with hepatitis B virus-related acute-on-chronic liver failure.
World J Gastroenterol
; 29(23): 3678-3687, 2023 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-37398886
ABSTRACT
BACKGROUND:
The lymphocyte-to-white blood cell ratio (LWR) is a blood marker of the systemic inflammatory response. The prognostic value of LWR in patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF) remains unclear.AIM:
To explore whether LWR could stratify the risk of poor outcomes in HBV-ACLF patients.METHODS:
This study was conducted by recruiting 330 patients with HBV-ACLF at the Department of Gastroenterology in a large tertiary hospital. Patients were divided into survivor and non-survivor groups according to their 28-d prognosis. The independent risk factors for 28-d mortality were calculated by univariate and multivariate Cox regression analyses. Patients were divided into low- and high-LWR groups according to the cutoff values. Kaplan-Meier analysis was performed according to the level of LWR.RESULTS:
During the 28-d follow-up time, 135 patients died, and the mortality rate was 40.90%. The LWR level in non-surviving patients was significantly decreased compared to that in surviving patients. A lower LWR level was an independent risk factor for poor 28-d outcomes (hazard ratio = 0.052, 95% confidence interval 0.005-0.535). The LWR level was significantly negatively correlated with the Child-Turcotte-Pugh, model for end-stage liver disease, and Chinese Group on the Study of Severe Hepatitis B-ACLF II scores. In addition, the 28-d mortality was higher for patients with LWR < 0.11 than for those with LWR ≥ 0.11.CONCLUSION:
LWR may serve as a simple and useful tool for stratifying the risk of poor 28-d outcomes in HBV-ACLF patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hepatite B Crônica
/
Doença Hepática Terminal
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Insuficiência Hepática Crônica Agudizada
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Hepatite B
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article