Serum levels of serum amyloid A, interleukin-6 and C-reactive protein correlate with severity of hidradenitis suppurativa.
Ital J Dermatol Venerol
; 158(4): 341-346, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37404192
ABSTRACT
BACKGROUND:
Validated biomarkers enabling an objective, dynamic assessment of hidradenitis suppurativa (HS) disease severity do not exist. The aim of our study was to determine the serum concentration of four potential biomarkers with respect to HS disease severity.METHODS:
We recruited 50 patients with hidradenitis suppurativa. After obtaining informed consent, patients were requested to fill out multiple questionnaires. Severity of HS was determined based on Hurley and Sartorius scores by an experienced dermatologist. Blood sampling included Serum Amyloid A (SAA), Interleukin-6 (IL-6), C-reactive protein (CRP) and S100 protein (S100) in a certified laboratory.RESULTS:
Moderate and statistically significant correlations of SAA, IL-6 and CRP with the clinical scores Hurley and Sartorius were observed. The respective Spearman's correlation coefficients (r) were Hurley 0.38, 0.46, 0.35 and Sartorius 0.51, 0.48, 0.48. No relevant changes were detected when comparing S100 to both Hurley (r=0.06) and Sartorius (r=0.09).CONCLUSIONS:
Our data suggest that an association between SAA, IL-6, CRP and HS disease severity could exist. Further research is needed to define their potential as biomarkers for quantifying and monitoring disease activity and response to treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína Amiloide A Sérica
/
Proteína C-Reativa
/
Interleucina-6
/
Hidradenite Supurativa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article