Discovery of YK-029A, a novel mutant EGFR inhibitor targeting both T790 M and exon 20 insertion mutations, as a treatment for NSCLC.

Liu, Bin; Gao, Feng; Zhao, Hui; Yuan, Shuai; Peng, Xingzhe; Zhang, Pengzhi; Wang, Jing; Zhang, Tongmei; Duan, Maosheng; Guo, Yongqi

Discovery of YK-029A, a novel mutant EGFR inhibitor targeting both T790 M and exon 20 insertion mutations, as a treatment for NSCLC.

Liu, Bin; Gao, Feng; Zhao, Hui; Yuan, Shuai; Peng, Xingzhe; Zhang, Pengzhi; Wang, Jing; Zhang, Tongmei; Duan, Maosheng; Guo, Yongqi.

Afiliação

Liu B; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China. Electronic address: lb@puhebiopharma.com.
Gao F; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Zhao H; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Yuan S; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Peng X; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Zhang P; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Wang J; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China.
Zhang T; Yuekang Biomedicines Co., Ltd, Room 601, Nanyang Building, Esplanade Avenue 81, Haikou, Hainan province, China.
Duan M; Yuekang Biomedicines Co., Ltd, Room 601, Nanyang Building, Esplanade Avenue 81, Haikou, Hainan province, China. Electronic address: duanmaosheng@yuezhikangtai.com.
Guo Y; Puhe Biopharma, Wu Song Jiang Avenue 1-1-19, Guo Xiang Street, Soochow, Jiangsu province, China. Electronic address: gyq@puhebiopharma.com.

Eur J Med Chem ; 258: 115590, 2023 Oct 05.

Article em En | MEDLINE | ID: mdl-37406381

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Animais; Humanos; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Mutagênese Insercional; Receptores ErbB/genética; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Carcinoma Pulmonar de Células não Pequenas/patologia; Mutação; Éxons; Modelos Animais de Doenças; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico

Palavras-chave

Diarrhea and rash; EGFR exon 20 insertion mutations; Non-small cell lung cancer (NSCLC); T790 M mutations; Tumor regression

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google