Ferroptosis: A potential therapeutic target in autoimmune disease (Review).
Exp Ther Med
; 26(2): 368, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37408857
ABSTRACT
Ferroptosis is a distinct type of regulated cell death characterized by iron overload and lipid peroxidation. Ferroptosis is regulated by numerous factors and controlled by several mechanisms. This cell death type has a relationship with the immune system, which may be regulated by damage-associated molecular patterns. Ferroptosis participates in the progression of autoimmune diseases, including autoimmune hepatitis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, psoriasis and insulin-dependent diabetes mellitus. The present review summarizes the role of ferroptosis in autoimmune disorders and discusses ferroptosis as a potential therapeutic target for autoimmune disease.
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MEDLINE
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Ano de publicação:
2023
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Article