Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities.

Das, Bhaba K; Kannan, Aarthi; Velasco, Graham J; Kunika, Mikaela D; Lambrecht, Nils; Nguyen, Quy; Zhao, Haibo; Wu, Jie; Gao, Ling

Das, Bhaba K; Kannan, Aarthi; Velasco, Graham J; Kunika, Mikaela D; Lambrecht, Nils; Nguyen, Quy; Zhao, Haibo; Wu, Jie; Gao, Ling.

Afiliação

Das BK; Southern California Institute for Research and Education, Long Beach, CA 90822, USA.
Kannan A; Southern California Institute for Research and Education, Long Beach, CA 90822, USA; Department of Dermatology, University of California-Irvine, Irvine, CA 92697, USA.
Velasco GJ; Pathology Department, Tibor Rubin VA Medical Center, VA Long Beach Healthcare System, Long Beach, CA 90822, USA.
Kunika MD; Southern California Institute for Research and Education, Long Beach, CA 90822, USA.
Lambrecht N; Pathology Department, Tibor Rubin VA Medical Center, VA Long Beach Healthcare System, Long Beach, CA 90822, USA.
Nguyen Q; Genomics Research and Technology Hub, Department of Biological Chemistry, University of California-Irvine, Irvine, CA 92697, USA.
Zhao H; Southern California Institute for Research and Education, Long Beach, CA 90822, USA.
Wu J; Genomics Research and Technology Hub, Department of Biological Chemistry, University of California-Irvine, Irvine, CA 92697, USA.
Gao L; Southern California Institute for Research and Education, Long Beach, CA 90822, USA; Department of Dermatology, University of California-Irvine, Irvine, CA 92697, USA; Dermatology Section, Tibor Rubin VA Medical Center, VA Long Beach Healthcare System, Long Beach, CA 90822, USA. Electronic address:

Cell Rep Med ; 4(7): 101101, 2023 07 18.

Article em En | MEDLINE | ID: mdl-37421947

Assuntos

Carcinoma de Célula de Merkel; Neoplasias Cutâneas; Humanos; Carcinoma de Célula de Merkel/tratamento farmacológico; Carcinoma de Célula de Merkel/genética; Carcinoma de Célula de Merkel/patologia; Transcriptoma/genética; Neoplasias Cutâneas/tratamento farmacológico; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/patologia; Imunoterapia; Perfilação da Expressão Gênica

Palavras-chave

Merkel cell carcinoma; cellular plasticity; copanlisib; epigenetics; immunotherapy resistance; neuroendocrine carcinoma; single cell RNA-seq; skin cancer; tumor cell state; tumor heterogeneity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Célula de Merkel Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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