Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma.
Cancer Metastasis Rev
; 42(3): 1021-1054, 2023 09.
Article
em En
| MEDLINE
| ID: mdl-37422534
ABSTRACT
Neuroendocrine neoplasms (NENs), which are characterized by neuroendocrine differentiation, can arise in various organs. NENs have been divided into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) based on morphological differentiation, each of which has a distinct etiology, molecular profile, and clinicopathological features. While the majority of NECs originate in the pulmonary organs, extrapulmonary NECs occur most predominantly in the gastro-entero-pancreatic (GEP) system. Although platinum-based chemotherapy is the main therapeutic option for recurrent or metastatic GEP-NEC patients, the clinical benefits are limited and associated with a poor prognosis, indicating the clinically urgent need for effective therapeutic agents. The clinical development of molecular-targeted therapies has been hampered due to the rarity of GEP-NECs and the paucity of knowledge on their biology. In this review, we summarize the biology, current treatments, and molecular profiles of GEP-NECs based on the findings of pivotal comprehensive molecular analyses; we also highlight potent therapeutic targets for future precision medicine based on the most recent results of clinical trials.
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MEDLINE
Assunto principal:
Neoplasias Pancreáticas
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Neoplasias Gástricas
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Tumores Neuroendócrinos
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Carcinoma Neuroendócrino
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Neoplasias Intestinais
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article