Genetically-regulated pathway-polygenic risk score (GRPa-PRS): A risk stratification method to identify genetically regulated pathways in polygenic diseases.

Li, Xiaoyang; Fernandes, Brisa S; Liu, Andi; Lu, Yimei; Chen, Jingchun; Zhao, Zhongming; Dai, Yulin

Li, Xiaoyang; Fernandes, Brisa S; Liu, Andi; Lu, Yimei; Chen, Jingchun; Zhao, Zhongming; Dai, Yulin.

Afiliação

Li X; Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Fernandes BS; Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Liu A; Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Lu Y; Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Chen J; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Zhao Z; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.
Dai Y; Nevada Institute of Personalized Medicine, University of Nevada Las Vegas, Las Vegas, NV 89154, USA.

medRxiv ; 2023 Jun 27.

Article em En | MEDLINE | ID: mdl-37425929