A nondepleting anti-CD19 antibody impairs B cell function and inhibits autoimmune diseases.
JCI Insight
; 8(13)2023 07 10.
Article
em En
| MEDLINE
| ID: mdl-37427592
ABSTRACT
B cells contribute to multiple aspects of autoimmune disorders, and B cell-targeting therapies, including B cell depletion, have been proven to be efficacious in treatment of multiple autoimmune diseases. However, the development of novel therapies targeting B cells with higher efficacy and a nondepleting mechanism of action is highly desirable. Here we describe a nondepleting, high-affinity anti-human CD19 antibody LY3541860 that exhibits potent B cell inhibitory activities. LY3541860 inhibits B cell activation, proliferation, and differentiation of primary human B cells with high potency. LY3541860 also inhibits human B cell activities in vivo in humanized mice. Similarly, our potent anti-mCD19 antibody also demonstrates improved efficacy over CD20 B cell depletion therapy in multiple B cell-dependent autoimmune disease models. Our data indicate that anti-CD19 antibody is a highly potent B cell inhibitor that may have potential to demonstrate improved efficacy over currently available B cell-targeting therapies in treatment of autoimmune conditions without causing B cell depletion.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Linfócitos B
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article