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Guided Metabolic Detoxification Program Supports Phase II Detoxification Enzymes and Antioxidant Balance in Healthy Participants.
Panda, Chinmayee; Komarnytsky, Slavko; Fleming, Michelle Norton; Marsh, Carissa; Barron, Keri; Le Brun-Blashka, Sara; Metzger, Brandon.
Afiliação
  • Panda C; Nutrition Innovation Center, Standard Process Inc., 150 N Research Campus Dr, Kannapolis, NC 28081, USA.
  • Komarnytsky S; Plants for Human Health Institute, NC State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
  • Fleming MN; Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, 400 Dan Allen Drive, Raleigh, NC 27695, USA.
  • Marsh C; College of Chiropractic, Northwestern Health Sciences University, 2501 W 84th Street, Bloomington, MN 55431, USA.
  • Barron K; College of Chiropractic, Northwestern Health Sciences University, 2501 W 84th Street, Bloomington, MN 55431, USA.
  • Le Brun-Blashka S; Nutrition Innovation Center, Standard Process Inc., 150 N Research Campus Dr, Kannapolis, NC 28081, USA.
  • Metzger B; Nutrition Innovation Center, Standard Process Inc., 150 N Research Campus Dr, Kannapolis, NC 28081, USA.
Nutrients ; 15(9)2023 May 06.
Article em En | MEDLINE | ID: mdl-37432335
Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification. The emerging evidence suggests that certain classes of phytonutrients can help support the detoxification process by stimulating the liver to produce detoxification enzymes or acting as antioxidants that neutralize the harmful effects of free radicals. This study was designed to examine the effects of a guided 28-day metabolic detoxification program in healthy adults. The participants were randomly assigned to consume a whole food, multi-ingredient supplement (n = 14, education and intervention) or control (n = 18, education and healthy meal) daily for the duration of the trial. The whole food supplement contained 37 g/serving of a proprietary, multicomponent nutritional blend in the form of a rehydratable shake. Program readiness was ensured at baseline using a validated self-perceived wellness score and a blood metabolic panel, indicating stable emotional and physical well-being in both groups. No significant changes or adverse effects were found on physical or emotional health, cellular glutathione (GSH) and the GSH:GSSG ratio, porphyrin, and hepatic detoxification biomarkers in urine. The intervention was positively associated with a 23% increase in superoxide dismutase (p = 0.06) and a 13% increase in glutathione S-transferase (p = 0.003) activities in the blood. This resulted in a 40% increase in the total cellular antioxidant capacity (p = 0.001) and a 13% decrease in reactive oxygen species (p = 0.002) in isolated PBMCs from participants in the detoxification group. Our findings indicate that consuming a whole food nutritional intervention as a part of the guided detoxification program supported phase II detoxification, in part, by promoting enhanced free radical scavenging and maintaining redox homeostasis under the body's natural glutathione recycling capacity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desintoxicação Metabólica Fase II / Antioxidantes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desintoxicação Metabólica Fase II / Antioxidantes Idioma: En Ano de publicação: 2023 Tipo de documento: Article