Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer.

Xu, Xinsheng; Cui, Lihua; Zhang, Lanqiu; Yang, Lei; Zhuo, Yuzhen; Li, Caixia

Xu, Xinsheng; Cui, Lihua; Zhang, Lanqiu; Yang, Lei; Zhuo, Yuzhen; Li, Caixia.

Afiliação

Xu X; Hepatopancreatobiliary Surgery Department, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China.
Cui L; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China.
Zhang L; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China.
Yang L; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China.
Zhuo Y; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China.
Li C; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Acute Abdominal Diseases of Integrated Traditional Chinese and Western Medicine, Tianjin Nankai Hospital, Nankai Clinical College, Tianjin Medical University, Tianjin, China. Electronic address: li

Int Immunopharmacol ; 122: 110579, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37433245

Assuntos

Carcinoma Ductal Pancreático; Neoplasias Pancreáticas; Saponinas; Camundongos; Animais; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Macrófagos Associados a Tumor/metabolismo; Modelos Animais de Doenças; Neoplasias Pancreáticas/genética; Serina-Treonina Quinases TOR/metabolismo; Saponinas/farmacologia; Saponinas/uso terapêutico; Carcinoma Ductal Pancreático/patologia; Microambiente Tumoral; Neoplasias Pancreáticas

Palavras-chave

M2 macrophage; PI3K/AKT/mTOR; Pancreatic Cancer; STAT6; Saikosaponin d

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Saponinas / Carcinoma Ductal Pancreático Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google