A transition metal- and photosensitizer-free approach for site-selective (hetero)arylation of polychlorinated heteroarenes.
Chem Commun (Camb)
; 59(62): 9513-9516, 2023 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-37455614
ABSTRACT
We have developed an effective photochemical method for site-selective (hetero)arylation of polychlorinated heteroarenes. This approach eliminates the need for transition metal catalysts and photosensitizers by relying on in situ formation of unconventional electron donor-acceptor (EDA) complexes between two substrates and a basic additive. Our protocol yields chlorine-containing biaryl heterocyclic compounds with high levels of site-selectivity, which are of significant importance in both synthetic and medicinal chemistry.
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MEDLINE
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En
Ano de publicação:
2023
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Article