Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity.

Wan, Li; Toland, Sabrina; Robinson-McCarthy, Lindsey R; Lee, Nara; Schaich, Matthew A; Hengel, Sarah R; Li, Xiaochen; Bernstein, Kara A; Van Houten, Bennett; Chang, Yuan; Moore, Patrick S

Wan, Li; Toland, Sabrina; Robinson-McCarthy, Lindsey R; Lee, Nara; Schaich, Matthew A; Hengel, Sarah R; Li, Xiaochen; Bernstein, Kara A; Van Houten, Bennett; Chang, Yuan; Moore, Patrick S.

Afiliação

Wan L; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213.
Toland S; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213.
Robinson-McCarthy LR; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213.
Lee N; Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA 15219.
Schaich MA; Genome Stability Program, Hillman Cancer Center, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15232.
Hengel SR; Department of Pharmacology, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232.
Li X; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213.
Bernstein KA; School of Medicine, Tsinghua University, Beijing 100084, China.
Van Houten B; Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Chang Y; Genome Stability Program, Hillman Cancer Center, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15232.
Moore PS; Cancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213.

Proc Natl Acad Sci U S A ; 120(30): e2308010120, 2023 07 25.

Article em En | MEDLINE | ID: mdl-37459531

Assuntos

Antígenos Transformantes de Poliomavirus; Vírus 40 dos Símios; Antígenos Transformantes de Poliomavirus/genética; Antígenos Transformantes de Poliomavirus/metabolismo; Vírus 40 dos Símios/genética; Vírus 40 dos Símios/metabolismo; Desnaturação de Ácido Nucleico; Adenilil Imidodifosfato; Replicação do DNA; DNA/genética; DNA/metabolismo; DNA Helicases/genética; DNA Helicases/metabolismo; DNA de Cadeia Simples; DNA Viral/genética; DNA Viral/metabolismo

Palavras-chave

Merkel cell polyomavirus; SV40 large T antigen; large T antigen helicase; single-molecule fluorescence microscopy; unlicensed origin replication

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos Transformantes de Poliomavirus / Vírus 40 dos Símios Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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