Your browser doesn't support javascript.
loading
The mediating role of exhaled breath condensate metabolites in the effect of particulate matter on pulmonary function in schoolchildren: A crossover intervention study.
Yang, Xiaoyan; Xu, Dongqun; Wen, Bo; Ji, Jian; Zhang, Zeyu; Li, Li; Zhang, Shaoping; Zhi, Hong; Kong, Jian; Wang, Chong; Wang, Jun; Ruan, Hongjie; Zhang, Ming; Wei, Lan; Dong, Bin; Wang, Qin.
Afiliação
  • Yang X; Key Laboratory of Environment and Human Health, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, C
  • Xu D; Key Laboratory of Environment and Human Health, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China; Department of Air Quality and Health Monitoring, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing
  • Wen B; Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191, China.
  • Ji J; Hazard Screening and Omic Platform, Analysis and Testing Center, Jiangnan University, Wuxi, Jiangsu 214122, China.
  • Zhang Z; Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
  • Li L; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Zhang S; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Zhi H; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Kong J; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Wang C; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Wang J; Key Laboratory of Environment and Human Health, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Ruan H; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Zhang M; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Wei L; Department of Environmental Toxicology, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Dong B; Department of Air Quality and Health Monitoring, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
  • Wang Q; Key Laboratory of Environment and Human Health, Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. Electronic address: wangqin@nieh.chinacdc.cn.
Sci Total Environ ; 898: 165517, 2023 Nov 10.
Article em En | MEDLINE | ID: mdl-37459994
The role played by metabolites in exhaled breath condensate (EBC) in the effect of PM on schoolchildren's pulmonary function has received little attention. Accordingly, we examined whether metabolites in EBC mediated the effect of PM10, PM2.5, and PM1 on the pulmonary function of schoolchildren at a residential primary school who had received an air-cleaner cross-over intervention. Samples of EBC were collected from a total of 60 schoolchildren and subjected to metabolomics analysis. We found that the effect of PM on six pulmonary function indicators was mediated by the following nine lipid peroxidation-related and energy metabolism-related metabolites present in EBC: 4-hydroxynonenal, arachidoyl ethanolamide, dl-pyroglutamic acid, 5-deoxy-d-glucose, myristic acid, lauric acid, linoleic acid, l-proline, and palmitic acid. However, while all nine of these metabolites mediated the effects of PM on boys' pulmonary function, only 4-hydroxynonenal, arachidoyl ethanolamide, and dl-pyroglutamic acid mediated the effects of PM on girls' pulmonary function. Overall, our results show that (1) short-term exposure to PM affected the schoolchildren's pulmonary function by causing an imbalance between lipid peroxidation and glutathione-based antioxidant activity and by perturbing energy metabolism in respiratory system and (2) there was a sex-dependent antioxidant response to PM exposure, with boys being less resistant than girls.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Pirrolidonocarboxílico / Material Particulado Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Pirrolidonocarboxílico / Material Particulado Idioma: En Ano de publicação: 2023 Tipo de documento: Article