Stereoselective study of fluoxetine and norfluoxetine across the blood-brain barrier mediated by organic cation transporter 1/3 in rats using an enantioselective UPLC-MS/MS method.

An, Hai; Fang, Jinjun; Wang, Min; Lin, Haiyang; Sun, Yingying; Hu, Bingying; He, Zhisheng; Ge, Zhen; Wei, Yang

An, Hai; Fang, Jinjun; Wang, Min; Lin, Haiyang; Sun, Yingying; Hu, Bingying; He, Zhisheng; Ge, Zhen; Wei, Yang.

Afiliação

An H; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Fang J; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wang M; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Lin H; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Sun Y; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Hu B; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
He Z; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Ge Z; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Wei Y; Zhejiang Key Laboratory of Neuropsychiatric Drug Research, School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Chirality ; 35(12): 983-992, 2023 12.

Article em En | MEDLINE | ID: mdl-37464916

Assuntos

Fluoxetina; Transportador 1 de Cátions Orgânicos; Ratos; Animais; Fluoxetina/análise; Fluoxetina/metabolismo; Transportador 1 de Cátions Orgânicos/metabolismo; Barreira Hematoencefálica; Cromatografia Líquida/métodos; Estereoisomerismo; Espectrometria de Massas em Tandem/métodos

Palavras-chave

antidepressant; central nervous system; chemical knockout; chiral analysis; configuration; metabolite

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluoxetina / Transportador 1 de Cátions Orgânicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fluoxetina / Transportador 1 de Cátions Orgânicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article