Recent advances in the development of metal complexes as antibacterial agents with metal-specific modes of action.
Curr Opin Microbiol
; 75: 102347, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37467616
ABSTRACT
The mounting burden of antimicrobial resistance (AMR) is one of the most concerning threats to public health worldwide. With low economic incentives and a dwindling supply of new drugs in clinical pipelines, more innovative approaches to novel drug design and development are desperately required. Metal-based compounds are rapidly emerging as an alternative to organic drugs, as they have the ability to kill pathogens via metal-specific modes of action. We herein review recent advances in metal-based antibacterial agents, including metal complexes, metal ions and catalytic metallodrugs. The review concludes with a perspective on the rational design of metal-based antibiotics, and how we can exploit their unique properties to tackle AMR.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexos de Coordenação
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article