Small change - big consequence: The impact of C15-C16 double bond in a D­ring of estrone on estrogen receptor activity.

Vonka, Petr; Rarova, Lucie; Bazgier, Vaclav; Tichy, Vlastimil; Kolarova, Tamara; Holcakova, Jitka; Berka, Karel; Kvasnica, Miroslav; Oklestkova, Jana; Kudova, Eva; Strnad, Miroslav; Hrstka, Roman

Small change - big consequence: The impact of C15-C16 double bond in a Dring of estrone on estrogen receptor activity.

Vonka, Petr; Rarova, Lucie; Bazgier, Vaclav; Tichy, Vlastimil; Kolarova, Tamara; Holcakova, Jitka; Berka, Karel; Kvasnica, Miroslav; Oklestkova, Jana; Kudova, Eva; Strnad, Miroslav; Hrstka, Roman.

Afiliação

Vonka P; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zlutý kopec 7, 656 53 Brno, Czech Republic; Laboratory of Growth Regulators, Faculty of Science of Palacký University & Institute of Experimental Botany of the Czech Academy of Sciences, Slechtitelu 27, 783 71 Olo
Rarova L; Department of Experimental Biology, Faculty of Science, Palacký University Olomouc, Slechtitelu 27, 78371 Olomouc, Czech Republic.
Bazgier V; Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, trída 17. listopadu 12, 771 46 Olomouc, Czech Republic.
Tichy V; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zlutý kopec 7, 656 53 Brno, Czech Republic.
Kolarova T; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zlutý kopec 7, 656 53 Brno, Czech Republic.
Holcakova J; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zlutý kopec 7, 656 53 Brno, Czech Republic.
Berka K; Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, trída 17. listopadu 12, 771 46 Olomouc, Czech Republic.
Kvasnica M; Laboratory of Growth Regulators, Faculty of Science of Palacký University & Institute of Experimental Botany of the Czech Academy of Sciences, Slechtitelu 27, 783 71 Olomouc, Czech Republic.
Oklestkova J; Laboratory of Growth Regulators, Faculty of Science of Palacký University & Institute of Experimental Botany of the Czech Academy of Sciences, Slechtitelu 27, 783 71 Olomouc, Czech Republic.
Kudova E; Institute of Organic Chemistry and Biochemistry AS CR, Flemingovo námestí 2, 166 10, Praha 6, Czech Republic.
Strnad M; Laboratory of Growth Regulators, Faculty of Science of Palacký University & Institute of Experimental Botany of the Czech Academy of Sciences, Slechtitelu 27, 783 71 Olomouc, Czech Republic.
Hrstka R; Research Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zlutý kopec 7, 656 53 Brno, Czech Republic; Laboratory of Growth Regulators, Faculty of Science of Palacký University & Institute of Experimental Botany of the Czech Academy of Sciences, Slechtitelu 27, 783 71 Olo

J Steroid Biochem Mol Biol ; 233: 106365, 2023 10.

Article em En | MEDLINE | ID: mdl-37468002

Assuntos

Neoplasias da Mama; Estrona; Humanos; Feminino; Fulvestranto/farmacologia; Fulvestranto/uso terapêutico; Estrona/farmacologia; Receptores de Estrogênio/metabolismo; Simulação de Acoplamento Molecular; Linhagem Celular Tumoral; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/metabolismo; Tamoxifeno/farmacologia; Receptor alfa de Estrogênio/genética; Receptor alfa de Estrogênio/metabolismo; Estradiol/farmacologia; Estradiol/uso terapêutico

Palavras-chave

Apoptosis; Docking of steroid library; Estrogen receptor alpha; Luciferase assay; Mitochondrial membrane potential

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Estrona Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Estrona Idioma: En Ano de publicação: 2023 Tipo de documento: Article