Programmable Deuteration of Indoles via Reverse Deuterium Exchange.
J Org Chem
; 88(15): 10772-10776, 2023 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-37477980
ABSTRACT
Methods for selective deuterium incorporation into drug-like molecules have become extremely valuable due to the commercial, mechanistic, and biological importance of deuterated compounds. Herein, we report a programmable labeling platform that allows access to C2, C3, or C2- and C3-deuterated indoles under mild, user-friendly conditions. The C2-deuterated indoles are accessed using a reverse hydrogen isotope exchange strategy which represents the first non-directed C2-deuteration of indoles.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article