Development of the hematopoietic system: expanding the concept of hematopoietic stem cell-independent hematopoiesis.
Trends Cell Biol
; 34(2): 161-172, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-37481335
ABSTRACT
Hematopoietic stem cells (HSCs) give rise to nearly all blood cell types and play a central role in blood cell production in adulthood. For many years it was assumed that these roles were similarly responsible for driving the formation of the hematopoietic system during the embryonic period. However, detailed analysis of embryonic hematopoiesis has revealed the presence of hematopoietic cells that develop independently of HSCs both before and after HSC generation. Furthermore, it is becoming increasingly clear that HSCs are less involved in the production of functioning blood cells during the embryonic period when there is a much higher contribution from HSC-independent hematopoietic processes. We outline the current understanding and arguments for HSC-dependent and -independent hematopoiesis, mainly focusing on mouse ontogeny.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Hematopoese
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article