Searching for molecular hypoxia sensors among oxygen-dependent enzymes.
Elife
; 122023 07 26.
Article
em En
| MEDLINE
| ID: mdl-37494095
ABSTRACT
The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes exist among aerobic organisms, raising the possibility that additional sensors remain to be discovered. This review summarizes known and potential hypoxia sensors among human O2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Hipóxia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article