Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis.

Qin, Tingting; Hasnat, Muhammad; Wang, Ziwei; Hassan, Hozeifa Mohamed; Zhou, Yang; Yuan, Ziqiao; Zhang, Wenzhou

Qin, Tingting; Hasnat, Muhammad; Wang, Ziwei; Hassan, Hozeifa Mohamed; Zhou, Yang; Yuan, Ziqiao; Zhang, Wenzhou.

Afiliação

Qin T; Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou University, Zhengzhou, PR China.
Hasnat M; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China; Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Wang Z; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China.
Hassan HM; Precision Medicine Center, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, PR China.
Zhou Y; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou University, Zhengzhou, PR China.
Yuan Z; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China. Electronic address: figaroyzq@zzu.edu.cn.
Zhang W; Department of Pharmacy, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou University, Zhengzhou, PR China. Electronic address: zlyyzhangwenzhou0551@zzu.edu.cn.

Phytomedicine ; 118: 154971, 2023 Sep.

Article em En | MEDLINE | ID: mdl-37494875

Assuntos

Inflamassomos; Fígado; Camundongos; Animais; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Ácidos e Sais Biliares/metabolismo; Sirtuína 1/metabolismo; Cromatografia Líquida; Camundongos Endogâmicos C57BL; Espectrometria de Massas em Tandem; Ductos Biliares/metabolismo; Fibrose; Cirrose Hepática/tratamento farmacológico; Cirrose Hepática/etiologia; Cirrose Hepática/metabolismo

Palavras-chave

Bile acid homeostasis; Cholestasis; Geniposide; NLRP3 inflammasome; SIRT1/FXR signaling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Fígado Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inflamassomos / Fígado Idioma: En Ano de publicação: 2023 Tipo de documento: Article