The ins-and-outs of exosome biogenesis, secretion, and internalization.
Trends Cell Biol
; 34(2): 90-108, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-37507251
ABSTRACT
Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of exosomes during physiological and pathological events has been extensively reported, there remains a lack of understanding of the mechanisms that regulate exosome biogenesis, secretion, and internalization. Recent technological and methodological advances now provide details about MVB/exosome structure as well as the pathways of exosome biogenesis, secretion, and uptake. In this review, we outline our current understanding of these processes and highlight outstanding questions following on recent discoveries in the field.
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Base de dados:
MEDLINE
Assunto principal:
Exossomos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article