An RNAi-Mediated Reduction in Transcription Factor Nrf-2 Blocks the Positive Effects of Dimethyl Fumarate on Metabolic Stress in Alzheimer's Disease.

Lanza, Marika; Basilotta, Rossella; Cuzzocrea, Salvatore; Bulzomì, Maria; Oddo, Salvatore; Casili, Giovanna; Esposito, Emanuela

Lanza, Marika; Basilotta, Rossella; Cuzzocrea, Salvatore; Bulzomì, Maria; Oddo, Salvatore; Casili, Giovanna; Esposito, Emanuela.

Afiliação

Lanza M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Basilotta R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Cuzzocrea S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Bulzomì M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Oddo S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Casili G; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
Esposito E; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.

Int J Mol Sci ; 24(14)2023 Jul 11.

Article em En | MEDLINE | ID: mdl-37511065

Assuntos

Doença de Alzheimer; Fumarato de Dimetilo; Fármacos Neuroprotetores; Interferência de RNA; Humanos; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/genética; Fumarato de Dimetilo/farmacologia; Fumarato de Dimetilo/uso terapêutico; Fármacos Neuroprotetores/farmacologia; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo; Linhagem Celular Tumoral

Palavras-chave

Alzheimer's disease; brain; metabolic stress; neurodegeneration; neuroinflammation; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fármacos Neuroprotetores / Interferência de RNA / Doença de Alzheimer / Fumarato de Dimetilo Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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