Intranasally Administered MSC-Derived Extracellular Vesicles Reverse Cisplatin-Induced Cognitive Impairment.

Milutinovic, Bojana; Mahalingam, Rajasekaran; Mendt, Mayela; Arroyo, Luis; Seua, Alexandre; Dharmaraj, Shruti; Shpall, Elizabeth; Heijnen, Cobi J

Milutinovic, Bojana; Mahalingam, Rajasekaran; Mendt, Mayela; Arroyo, Luis; Seua, Alexandre; Dharmaraj, Shruti; Shpall, Elizabeth; Heijnen, Cobi J.

Afiliação

Milutinovic B; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mahalingam R; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mendt M; Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Arroyo L; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Seua A; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Dharmaraj S; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shpall E; Department of Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Heijnen CJ; Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Int J Mol Sci ; 24(14)2023 Jul 24.

Article em En | MEDLINE | ID: mdl-37511623

Assuntos

Transtornos Cognitivos; Disfunção Cognitiva; Vesículas Extracelulares; Camundongos; Animais; Cisplatino/efeitos adversos; Disfunção Cognitiva/induzido quimicamente; Disfunção Cognitiva/terapia; Encéfalo; Transtornos Cognitivos/induzido quimicamente

Palavras-chave

MSC; chemobrain; cognition; extracellular vesicle; mitochondria; synaptic integrity; white matter

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Disfunção Cognitiva / Vesículas Extracelulares Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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