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The subglottic involvement is an independent risk factor for recurrence of laryngeal amyloidosis.
Shi, Yao; Xie, Meng; Zhang, Qing-Qing; Guo, Rui-Xin; Qiang, Yin; Yang, Hao-Nan; Liu, Xiao-Hong; Luo, Hua-Nan.
Afiliação
  • Shi Y; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Xie M; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Zhang QQ; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Guo RX; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Qiang Y; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Yang HN; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China.
  • Liu XH; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China. lrf1999lxh@163.com.
  • Luo HN; Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, No. 157 Xi-Wu Road, Xi'an, 710004, Shannxi, China. luohuanan@126.com.
Eur Arch Otorhinolaryngol ; 280(11): 5003-5009, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37515635
ABSTRACT

OBJECTIVE:

To analyze the risk factors for recurrence of laryngeal amyloidosis (LA).

METHODS:

The clinical data of patients with LA admitted in the Otolaryngology Head and Neck Surgery Department of the Second Affiliated Hospital of Xi'an Jiaotong University from August 2009 to June 2022 were analyzed retrospectively; then, the risk factors for recurrence and their impacts on the recurrence time were also analyzed.

RESULTS:

Of the 44 patients with LA, the majority (38 cases, 86.4%) only involved one anatomical region and the others (6 cases, 13.6%) involved two laryngeal regions concurrently. Overall, the glottic region was the most commonly affected area (28 cases, 63.6%), followed by the supraglottic region (16 cases, 36.4%) and subglottic region (6 cases, 13.6%). In addition, all the lesions were categorized as isolated nodule (31.8%), submucosal localized deposition (52.3%), and submucosal diffuse deposition (15.9%) according to their morphologies under electronic laryngoscope. Finally, six patients (13.6%) had recurrence after operation with a median recurrence time of 24.5 months, and subglottic involvement was confirmed to be an independent risk factor for recurrence of LA by univariate and multivariate logistic regression analyses (P < 0.05). Meanwhile, the patients with subglottic involvement presented as submucosal diffuse deposition had a considerable shorter recurrence time (t = 5.759, P = 0.005).

CONCLUSION:

The subglottic involvement is an independent risk factor for recurrence of LA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Laríngeas / Amiloidose / Laringe Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Laríngeas / Amiloidose / Laringe Idioma: En Ano de publicação: 2023 Tipo de documento: Article