Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue.

Green, Jonathan; Tinson, Ryan A J; Betts, Jacob H J; Piras, Monica; Pelut, Aylin; Steverding, Dietmar; Wren, Stephen P; Searcey, Mark; Troeberg, Linda

Green, Jonathan; Tinson, Ryan A J; Betts, Jacob H J; Piras, Monica; Pelut, Aylin; Steverding, Dietmar; Wren, Stephen P; Searcey, Mark; Troeberg, Linda.

Afiliação

Green J; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom.
Tinson RAJ; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Betts JHJ; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom.
Piras M; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, United Kingdom.
Pelut A; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom.
Steverding D; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom.
Wren SP; Target Discovery Institute, University of Oxford, Oxford OX3 7FZ, United Kingdom; Department of Chemical and Pharmaceutical Sciences, Kingston University, Kingston upon Thames KT1 2EE, United Kingdom.
Searcey M; School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Troeberg L; Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, United Kingdom. Electronic address: l.troeberg@uea.ac.uk.

Bioorg Med Chem ; 92: 117424, 2023 09 07.

Article em En | MEDLINE | ID: mdl-37517101

Assuntos

Osteoartrite; Inibidor Tecidual de Metaloproteinase-3; Humanos; Inibidor Tecidual de Metaloproteinase-3/metabolismo; Inibidor Tecidual de Metaloproteinase-3/farmacologia; Inibidor Tecidual de Metaloproteinase-3/uso terapêutico; Suramina/farmacologia; Suramina/metabolismo; Suramina/uso terapêutico; Cartilagem/metabolismo; Osteoartrite/tratamento farmacológico; Osteoartrite/metabolismo; Metaloproteases/metabolismo; Metaloproteases/farmacologia; Metaloproteases/uso terapêutico

Palavras-chave

LRP1; Low-density lipoprotein receptor-related protein 1; Osteoarthritis; Suramin; TIMP-3

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Inibidor Tecidual de Metaloproteinase-3 Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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