Mechanotransduction through hemidesmosomes during aging and longevity.
J Cell Sci
; 136(15)2023 08 01.
Article
em En
| MEDLINE
| ID: mdl-37522320
ABSTRACT
Hemidesmosomes are structural protein complexes localized at the interface of tissues with high mechanical demand and shear forces. Beyond tissue anchoring, hemidesmosomes have emerged as force-modulating structures important for translating mechanical cues into biochemical and transcriptional adaptation (i.e. mechanotransduction) across tissues. Here, we discuss the recent insights into the roles of hemidesmosomes in age-related tissue regeneration and aging in C. elegans, mice and humans. We highlight the emerging concept of preserved dynamic mechanoregulation of hemidesmosomes in tissue maintenance and healthy aging.
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MEDLINE
Assunto principal:
Hemidesmossomos
/
Proteínas de Caenorhabditis elegans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article