TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?
Hematol Oncol
; 41(5): 942-946, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-37534633
ABSTRACT
TNFRSF13B mutations are widely associated with common variable immunodeficiency. TNFRSF13B was recently counted among relevant genes associated with childhood-onset of hematological malignancies; nonetheless, its role in acute myeloid leukemia (AML) remains unexplored. We report the study of a family with two cases of AML, sharing a germline TNFRSF13B mutation favoring the formation of a more stable complex with its ligand TNFSF13 a positive regulator of AML-initiating cells. Our data turn the spotlight onto the TNFRSF13B role in AML onset, inserting a new fragment into the complex scenario of a hereditary predisposition to myeloid neoplasms.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Neoplasias Hematológicas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article