Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome.

Adams, April D; Lin, Jielu; Bianchi, Diana W; Bishop, Lauren; Sato, Taisuke; Baxter, Laura L; Hoffmann, Victoria; Koehly, Laura; Guedj, Faycal

Adams, April D; Lin, Jielu; Bianchi, Diana W; Bishop, Lauren; Sato, Taisuke; Baxter, Laura L; Hoffmann, Victoria; Koehly, Laura; Guedj, Faycal.

Afiliação

Adams AD; Section on Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX.
Lin J; Section on Social Network Methods, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Bianchi DW; Section on Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. E
Bishop L; Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD; Department of Obstetrics and Gynecology, Columbia University School of Medicine, New York, NY.
Sato T; Section on Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Baxter LL; Section on Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Hoffmann V; Division of Veterinary Resources, Office of the Director, National Institutes of Health, Bethesda, MD.
Koehly L; Section on Social Network Methods, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Guedj F; Section on Prenatal Genomics and Fetal Therapy, Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

Am J Obstet Gynecol ; 230(2): 258.e1-258.e11, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37544351

Assuntos

Síndrome de Down; Cardiopatias Congênitas; Deficiência Intelectual; Animais; Camundongos; Feminino; Humanos; Gravidez; Síndrome de Down/genética; Placenta; Fenótipo; Cardiopatias Congênitas/genética; Biomarcadores; Modelos Animais de Doenças; Camundongos Endogâmicos C57BL

Palavras-chave

Down syndrome; Ts66Yah; biomarkers; fetal growth; mouse models; phenotype severity; placental development

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome de Down / Cardiopatias Congênitas / Deficiência Intelectual Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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