Enhanced activity against a third-generation cephalosporin by destabilization of the active site of a class A beta-lactamase.

Sun, Jing; Chikunova, Aleksandra; Boyle, Aimee L; Voskamp, Patrick; Timmer, Monika; Ubbink, Marcellus.

Afiliação

Sun J; Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Chikunova A; Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Boyle AL; Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Voskamp P; Biophysical Structural Chemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Timmer M; Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands.
Ubbink M; Macromolecular Biochemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, the Netherlands. Electronic address: m.ubbink@chem.leidenuniv.nl.

Int J Biol Macromol ; 250: 126160, 2023 Oct 01.

Article em En | MEDLINE | ID: mdl-37549761